National G6PD neonatal screening program in Gaza Strip of Palestine: rationale, challenges and recommendations.

Sirdah, Mahmoud; Al-Kahlout, Mustafa S.; Reading, N. Scott

dc.contributor.author	Sirdah, Mahmoud
dc.contributor.author	Al-Kahlout, Mustafa S.
dc.contributor.author	Reading, N. Scott
dc.date.accessioned	2019-05-20T07:45:23Z
dc.date.available	2019-05-20T07:45:23Z
dc.date.issued	2016
dc.identifier.citation	Clin Genet. 2016 Sep;90(3):191-8. doi: 10.1111/cge.12786	en_US
dc.identifier.uri	http://dspace.alazhar.edu.ps/xmlui/handle/123456789/254
dc.description.abstract	Abstract Congenital genetic disorders affecting neonates or young children can have serious clinical consequences if undiagnosed and left untreated. Early detection and an accurate diagnosis are, therefore, of major importance for preventing negative patient outcomes. Even though the occurrence of each specific metabolic disorder may be rare, their collective impact of preventable complications may be of considerable importance to the public health. Our previous studies showed that glucose-6-phosphate dehydrogenase (G6PD) deficiency is a problem of public health importance that has been shown to be a predominant cause of acute hemolytic anemia requiring hospitalization in Palestinian young children in Gaza Strip. Intriguingly, the majority of these children had one of the three variants, Mediterranean(c.) (563T) , African G6PD A-(c.) (202A) (/c.) (376G) and heretofore unrecognized as a common G6PD-deficient variant G6PD Cairo(c.) (404C) . The high prevalence of G6PD deficiency, as well as dietary factors in the region that precipitate anemia, argues for a need to protect the Palestinian children from a treatable and manageable genetic and metabolic disorder. This work reviews and discusses rationales and challenges of G6PD screening program in Gaza Strip. We advocate adopting a national neonatal G6PD screening program in Gaza Strip to identify children at risk and promote wellness and health for Palestine.	en_US
dc.language.iso	en_US	en_US
dc.publisher	John Wiley & Sons	en_US
dc.subject	G6PD deficiency; Gaza Strip; Palestine; neonatal screening	en_US
dc.title	National G6PD neonatal screening program in Gaza Strip of Palestine: rationale, challenges and recommendations.	en_US
dc.type	Article	en_US