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Does cigarette smoking affect the diagnostic reliability of hemoglobin alpha 2 delta 2 (HbA2)?

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dc.contributor.author Tarazi, Issa S.
dc.contributor.author Sirdah, Mahmoud
dc.contributor.author El Jeadi, Hesham
dc.contributor.author Al Haddad, Rami M.
dc.date.accessioned 2019-05-20T16:16:11Z
dc.date.available 2019-05-20T16:16:11Z
dc.date.issued 2008
dc.identifier.citation J Clin Lab Anal. 2008;22(2):119-22. doi: 10.1002/jcla.20228 en_US
dc.identifier.uri http://dspace.alazhar.edu.ps/xmlui/handle/123456789/269
dc.description.abstract Abstract Quantitation of hemoglobin alpha 2 delta 2 (HbA2) is a basic and confirmatory test in diagnosing the carrier state of beta-thalassemia. The present study was designed to investigate the effect of cigarette smoking on the diagnostic reliability of HbA2. A total of 2,867 (654 smokers and 2,213 never smokers) male subjects were involved in the present study. The subjects were categorized into three groups according to their laboratory findings: beta-thalassemia minor, iron deficient, and normal groups. Complete blood count (CBC) parameters and HbA2 levels were compared between smokers and never smokers of each group according to the independent-samples t-test using the SPSS program, significance results were reported at P<0.05. The results showed a significant increase in red blood cell (RBC) mass (RBC count and hematocrit [Hct]) and Hb concentration in smokers of all groups; however, no significant differences were reported in the HbA2 level between smokers and never smokers in all groups. It was concluded that cigarette smoking does not affect the diagnostic reliability of the HbA2 test. en_US
dc.language.iso en_US en_US
dc.publisher John Wiley & Sons en_US
dc.subject HbA2; smoking; thalassemia; iron deficiency en_US
dc.title Does cigarette smoking affect the diagnostic reliability of hemoglobin alpha 2 delta 2 (HbA2)? en_US
dc.type Article en_US


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