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Expression of TBX2 among Breast Cancer Patients in Gaza Strip

Show simple item record Mwafy, Saleh Aliwaini, Saeb Attallah, Eman 2019-11-15T15:36:01Z 2019-11-15T15:36:01Z 2018-05-23
dc.description.abstract Background: Breast carcinomas considered as the most prevalent types among women and it is estimated that about one out of eight women will develop breast cancer in their lifetime. TBX2, a member of the T-box transcription factors, its over expressed in different types of carcinomas, according to cell proliferation and metastasis. Aim: To demonstrate the association between TBX2 over expression and breast cancer in Gaza strip. Material and Methods: This cross sectional study included 51 breast cancer samples and their crossbonding normal tissues were collected from the Gaza European Hospital in 2015-2016. Sections for (immuno-histopathology) from each sample were prepared and immune-stained by anti-TBX2 and suitable secondary and tertiary stains. TBX2 level was evaluated by pathologists in both cancer and normal samples. Clinical data for each patient was obtained from the hospital and correlations between these data and TBX2 level were statistically analyzed. Results: TBX2 was significantly overexpressed in breast cancer tissues in comparison to normal tissues. The overexpressions of TBX2 were recorded for all types and stages of breast cancer. No significant correlation were reported between TBX2 level and other breast cancer markers such as ER, PR, HER2 and CA15-3. Conclusions: TBX2 was associated and over expressed in breast cancer and due to its accuracy and specificity, its value as a breast cancer biomarker was higher than other markers in different studies. Consequently, TBX2 may be used as a potential biomarker for breast cancer. en_US
dc.language.iso en en_US
dc.publisher Al Azhar University-Gaza en_US
dc.subject TBX2, Breast cancer, Biomarker, Gaza Strip, Palestine en_US
dc.title Expression of TBX2 among Breast Cancer Patients in Gaza Strip en_US
dc.type Thesis en_US

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