The present study was aimed to investigate Lp(a) as a predictor of cardiovascular diseases among type 2 diabetic patients. This study is a case-control study composed of 100 T2DM patients without heart disease, and 100 T2DM patients diagnosed as heart disease and 100 normal individuals of age matching control. Questionnaire interviews were applied. Lp(a) and high sensitive (hs.CRP) were measured using immunoturbidimetric technique. Fasting blood sugar (FBS), creatine phosphokinase (CPK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), cholesterol (TC), Triglycerides (TG) and high density lipoprotein (HDL-C) were measured using colorimetric and kinetic methods. Low density lipoprotein (LDL) was calculated by empirical relationship of Friedewald. All ethical permission from local ethical committee was obtained before study conducting. Study showed that the levels of FBS, TC, TG, HDL, LDL, LDH, CPK, hs.CRP and Lp(a) were significantly increased among T2DM patients (P≤0.05)., In T2DM+HD, the level of FBG was significantly lower than its level in T2DM; LDH and CPK levels were significantly increased (P≤0.05). 51% of T2DM and 65% of T2DM+HD have high levels of Lp(a). High levels of hs.CRP were observed among 57% of T2DM and 63% among T2DM+DH. A positive correlation was found between Lp(a) and FBS, hs.CRP and LDL, while negative correlation was found with HDL level. Strong positive correlation was found between TC and LDL (r=0.894,P=0.001), and negative correlation was found with HDL (r=-0.512 P=0.001) respectively. Furthermore strong positive correlation was found between AST and CPK. There is a strong correlation between the presence of abnormal levels of Lp(a) and hs.CRP, T2DM and T2DM+HD. Lp(a) and hs.CRP may be considered as predictor, diagnostic and prognostic marker of CVD mortality and myocardia infraction among T2DM. Significant increased Lp(a) and hs.CRP were recorded among diabetic patients suffering from heart disease.