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 Aflatoxin B1 levels in chronic hepatitis B patients with or without cirrhosis and hepatocellular carcinoma in Gaza Strip Palestine

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dc.contributor.author Bayader B. Dahalan
dc.date.accessioned 21/10/2020
dc.date.accessioned 21/10/2020
dc.date.accessioned 2020-10-21T10:02:04Z
dc.date.available 21/10/2020
dc.date.available 2020-10-21T10:02:04Z
dc.date.issued 12/9/2019
dc.identifier.uri http://dspace.alazhar.edu.ps/xmlui/handle/123456789/993
dc.description.abstract ABSTRACT Introduction: Aflatoxins, the secondary metabolites produced by species of naturally occurring Aspergilli, are commonly found in food such as cereals, dried fruits juice, and spices. They are hepatotoxic and are well known human carcinogens based on evidence from human studies. Aflatoxins are an environmental risk factor for the development of hepatocellular carcinoma (HCC). Chronic hepatitis B patients are at increased risk of cirrhosis, hepatic failure and liver cancer. Aim: This study was designed to determine the serum aflatoxin B1 (AFB1) levels in chronic hepatitis B patients with or without cirrhosis and liver cancer, as well as in their matched control subjects, in Gaza-Strip. Methodology: This is a case-control study where Aflatoxin B1 levels in 40 blood samples of chronic hepatitis B patients and 40 blood samples of healthy subjects (control group) were determined using ELISA technique. Results: The mean AFB1 levels in chronic hepatitis B patients without liver cancer and cirrhosis were significantly higher than healthy controls . Conclusion: Results suggest that patients with chronic hepatitis B who are exposed to AFB1 are at increased risk for developing HCC, which might be prevented by reducing consumption of AFB1-contaminated foods. Also, according to the study, the presence of aflatoxin B1 in the blood of healthy control subjects is also an important risk factor to be considered, because it is evidence of the spread of aflatoxin B1 in the Gaza Strip and is a public health hazard. Key words: Aflatoxin B1, Chronic hepatitis B, Hepatocellular carcinoma, ELISA, Gaza. en_US
dc.language.iso en_US en_US
dc.title  Aflatoxin B1 levels in chronic hepatitis B patients with or without cirrhosis and hepatocellular carcinoma in Gaza Strip Palestine en_US
dc.type Thesis en_US


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